Calcium so you’re able to Phosphorus Ratio, PTH, and you may Bone Wellness

Calcium so you’re able to Phosphorus Ratio, PTH, and you may Bone Wellness

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Estimates because of the Ray Peat, PhD: “The latest ratio from calcium supplements to phosphate is essential; this is why dairy and you can parmesan cheese are incredibly worthwhile for losing weight, and for stopping putting on weight. For many who aren’t really energetic, zero fat milk and you can mozzarella cheese are better, while the surplus fat calorie consumption are not requisite.”

“The meals large in phosphate, prior to calcium supplements, is actually grain, legumes, meat, and seafood. Of a lot wishing ingredients incorporate additional phosphate. Products that have a higher, safe proportion out-of calcium supplements so you can phosphate try renders, for example kale, turnip greens, and you will beet greens, and many fruit, dairy, and you can cheese.”

Br J Nutr

“100 % free unsaturated essential fatty acids activate the pressure hormonal, and you can cortisol stops oxidation of sugar and you will transforms it towards the fatty acids and you will triglycerides. Keeping cortisol and you can stress low ‘s the head question. Keeping a top ratio away from calcium supplements so you can phosphate really helps to oppose pressure metabolic process.” “Current publication was demonstrating that extreme phosphate increases soreness, muscle atrophy, calcification of bloodstream, cancer tumors, alzhiemer’s disease, and, in general, the latest processes of ageing.”

2006 September;96(3):545-52. High phosphorus consumption exceedingly and negatively apply at Ca and bone metabolic process when you look at the a serving-based manner from inside the suit more youthful female. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. Ca and you can P was one another important nourishment for limbs and are usually known to apply to probably one of the most very important government out of bone metabolism, parathyroid hormone (PTH). Also ample a good P intake, typical away from West diets, will be deleterious to help you bones from enhanced PTH secretion. Few controlled dose-effect studies are available on the results out of highest P intake for the guy. I analyzed the fresh new short-title aftereffects of five P doses on the California and bone kcalorie burning when you look at the fourteen compliment lady, 20-twenty-eight years of age, who had been randomized to help you five managed analysis weeks; therefore per analysis subject offered since the her very own handle. P complement doses off 0 (placebo), 250, 750 or 1500 mg have been taken, divided in to around three dosages inside the studies go out. The dishes served up had been equivalent while in the for each and every research big date and you may provided 495 milligrams P and you may 250 milligrams Ca. The latest P dosage inspired the fresh serum PTH (S-PTH) from inside the a dose-oriented styles (P=0.0005). There clearly was a reduction in serum ionized Ca focus just in the the best P serving (P=0.004). The latest marker out-of limbs creation, bone-particular alkaline phosphatase, diminished (P=0.05) and the bones resorption marker, N-terminal telopeptide out-of collagen type of We, improved in response with the P doses (P=0.05). This managed dosage-reaction research indicated that P enjoys a serving-created impact on S-PTH and you may grows PTH secretion significantly whenever Ca intake try low. Acutely high P consumption adversely has an effect on bones metabolic rate by coming down bone creation and expanding limbs resorption, since indicated by the bone k-calorie burning markers.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.

Post a comment